Pdf the binary mixture of ampicillin sodium and sulbactam sodium is officially analyzed by hplc but can not be simultaneously determined. Sulbactam sodium is a weak antibiotic but its action a s an irreversible inhibitor of. Ampicillinsulbactam is a combination of antibiotics made up of ampicillin, a betalactam and sulbactam, a betalactamase inhibitor introduced in the eighties. The betalactam ring of sulbactam irreversibly binds to betalactamase at or near its active site, thereby blocking enzyme activity and preventing metabolism of other betalactam antibiotics by the enzyme. Chemically, sulbactam sodium is sodium penicillinate sulfone. Find here online price details of companies selling sulbactam sodium injection. Unasyn ampicillin sodiumsulbactam sodium pharmacy bulk. Our specialization, your confidencewe keep committing to meet the. It was patented in 1977 and approved for medical use in 1986. Cefaperazone is a semi synthetic broad spectrum cephalosporin antibiotic. Unasyn is an injectable antibacterial combination consisting of the semisynthetic antibacterial ampicillin sodium and the betalactamase inhibitor sulbactam sodium for intravenous and intramuscular administration ampicillin sodium is derived from the penicillin nucleus, 6aminopenicillanic acid. Unasyn dry powder is freely soluble in aqueous diluents to yield pale yellow to yellow solutions containing ampicillin sodium and sulbactam sodium equivalent to 250 mg ampicillin per ml and 125 mg sulbactam per ml. This medication is given by injection into a vein, usually every 6 hours or as directed by your doctor. Fixed combination of ampicillin sodium an aminopenicillin and sulbactam sodium a.
Overdosage of the drug would be expected to produce manifestations that are principally extensions of the adverse reactions reported with the drug. Ampicillinsulbactam is a combination of the common penicillinderived antibiotic ampicillin and sulbactam, an inhibitor of bacterial betalactamase. Dec 21, 2008 an isocratic liquid chromatographic method with uv detection at 220 nm is described for simultaneous determination of ceftriaxone sodium and sulbactam sodium in sulbactomax. Sulbactam sodium, chemical structure, molecular formula. Click on the desired brand to find out the drug price or cost of the drug. Sulbactam is a semisynthetic betalactamase inhibitor.
May be harmful by inhalation, ingestion, or skin absorption. Sulbactam sodium contains not less than 886g and not more than 941g of sulbactam c 8 h 11 no 5 sper mg,calculated on the anhydrous basis. Chemically, it is monosodium 2s, 5r, 6r6r2amino2phenylacetamido3. The antimicrobial effect of piperacillin can be enhanced by the two combined. Sulbactam sodium european pharmacopoeia ep reference standard. An isocratic liquid chromatographic method with uv detection at 220 nm is described for simultaneous determination of ceftriaxone sodium and sulbactam sodium in sulbactomax. Sulbactam sodium definition of sulbactam sodium by the. Comparative activities of the betalactamase inhibitors ytr. Your doctor will tell you how long to use ampicillin and sulbactam injection. Addition of sulbactam increases resistance to betalactamases, enzymes produced by bacteria that may inactivate ampicillin.
The sulbactam sodium and cefoperazone sodium combination consists of a betalactamase inhibitor plus a betalactam. Sulbactam is able to inhibit the most common forms of. A novel high performance liquid chromatographic method for. Accidental release measures contain spill and collect, as appropriate. At a concentration of 8 microgramsml, ytr 830 was as effective as clavulanate or sulbactam in reducing the aminopenicillin. Sulbactam sodiumampicillin sodium pfizer pro login page.
Asterisks are no longer used or included within the product and package code segments to indicate certain configurations of the ndc. May cause allergy or asthma symptoms or breathing difficulties if inhaled. Generic drug sulbactam sodium combination available with manufacturer details. Bhattacharya ss, bharti n, banerjee s 2014 process validation of ceftriaxone and sulbactam dry powder injection. Sulbactam sodium is also a derivative of 6aminopenicillanic acid. Chemically, it is known as either sodium penicillinate sulfone or sodium 2s, 5r3,3dimethyl7oxo4thia1azabicyclo3. A01ab antiinfectives and antiseptics for local oral treatment a02bd combinations for eradication of helicobacter pylori. The ddds for the antiinfectives are as a main rule based on the use in infections of moderate severity. Sulbactam sodium combination price of 25 brands trade. Ytr 830, a new betalactamase inhibitor, was compared with clavulanic acid and sulbactam against aminopenicillinresistant clinical isolates. Material safety data sheet of sulbactam sodium abmole. Usp dry powder is freely soluble in aqueous diluents to yield pale yellow to yellow solutions containing ampicillin sodium and sulbactam sodium equivalent to 250 mg ampicillin per ml and 125 mg sulbactam per ml. Unasyn ampicillin sodiumsulbactam sodium dose, indications.
Sulbactam sodium european pharmacopoeia ep reference. Learn about drug interactions between ampicillinsulbactam iv and sodium bicarbonate iv and use the rxlist drug interaction checker to check drug combinations. Ampicillin sodium and sulbactam sodium monograph for. Ampicillin and sulbactam for injection pharmacy bulk package is a vial containing a sterile preparation of ampicillin sodium and sulbactam sodium for parenteral use that contains many single doses. Limited information is available on the acute toxicity of cefoperazone sodium and sulbactam sodium in humans.
Dailymed ampicillin sodium and sulbactam sodium injection. Sulbactam sodium definition of sulbactam sodium by the free. Sulbactam definition of sulbactam by medical dictionary. The sodium content per vial is 1150 mg 50 meq sodium. Addition of sulbactam increases resistance to betalactamases, enzymes. Aug 06, 2015 unasyn ampicillin sodiumsulbactam sodium powder for injection msds special notice. Unasyn ampicillin sodium, sulbactam sodium how supplied. May 07, 2018 unasyn, ampicillin sodium sulbactam sodium parenteral combination, is available as a white to offwhite dry powder for reconstitution.
May 25, 2018 ampicillin and sulbactam for injection, usp dry powder is freely soluble in aqueous diluents to yield pale yellow to yellow solutions containing ampicillin sodium and sulbactam sodium equivalent to 250 mg ampicillin per ml and 125 mg sulbactam per ml. Antiinfectives are also classified in the following groups. Comparative activities of the betalactamase inhibitors ytr 830, sodium clavulanate, and sulbactam combined with amoxicillin or ampicillin. Amoxycillin sodium, sulbactam sodium, tetra butyl ammonium hydroxide. Unasyn ampicillin sodiumsulbactam sodium is supplied as a sterile offwhite dry powder in glass vials and piggyback bottles. The first, developed in 1987 and marketed in the united states under the tradename unasyn, generic only outside the united states, is an intravenous antibiotic. This sulbactam cefoperazone combination is available as a dry powder for reconstitution in a 1. A compound, c8h11no5s, that inhibits action of the enzyme betalactamase, thus counteracting bacterial resistance to betalactam antibiotics. Unasyn ampicillin sodiumsulbactam sodium powder for. Sulbactam sodium is a derivative of the basic penicillin nucleus. Dailymed ampicillin and sulbactam ampicillin sodium and. Sulbactam sodium is a semi synthetic penem antibiotic formed by the oxidation of penicillanic acid to its sulfone and was invented by barth at pfizer in 1978. Sulbactam sodium manufacturerhigh qualitybest pricein stock.
Stable for 8 hours at room temperature or 48 hours refrigerated at a maximum concentration of 45 mgml ampicillin. To reduce the development of drug resistant bacteria and maintain the effectiveness of. Unasyn ampicillin sodiumsulbactam sodium powder for injection. The length of treatment depends on the type of infection you have. Sulbactam sodium salt cas 69388847 scbt santa cruz. Pdf simultaneous determination of ampicillin sodium and. Chromatographic separation of two drugs was achieved on a hypersil ods c18 column using a mobile phase consisting of a binary mixture of acetonitrile and tetrabutyl. Sulbactam sodium synonyms, sulbactam sodium pronunciation, sulbactam sodium translation, english dictionary definition of sulbactam sodium. Unasyn ampicillin sodiumsulbactam sodium antibiotics.
How to use ampicillin sulbactam vial with threaded port. Piperacillin sodium and sulbactam sodium for injection2. However, some antiinfectives are only used in severe infections and their ddds are assigned accordingly. Comparative activities of the betalactamase inhibitors. Packaging and storage preserve in tight containers. Simultaneous determination of ampicillin sodium and sulbactam sodium in binary mixtures and commercial dosage forms using chemometricsassisted spectrophotometric techniques. Capitals indicate lifethreatening, underlines indicate most frequent. List of drug master files dmf of sulbactam sodium active pharmaceutical ingredient api submitted to the u. Its chemical formula is c8h10nnao5s with a molecular weight of 255. Drugs az pill identifier supplements symptom checker diseases dictionary media. Jan 03, 20 piperacillin sodium and sulbactam sodium for injection 2. Create pdf files without this message by purchasing novapdf printer. For research use only, not for human or veterinary use. Get info of suppliers, manufacturers, exporters, traders of sulbactam sodium injection for buying in india.